Sleep, Performance and Cognition

This cluster focuses on the neural and behavioral processes that regulate sleep, cognitive performance, and the effects of sleep loss on these processes, using both human and non-human animal models. The goal is to understand how sleep, or lack of sleep, can affect broad aspects of health and performance.

Recent research in this area

Davis, C. J., & Vanderheyden, W.M. (2020) Optogenetic sleep enhancement improves fear-associated memory processing following trauma exposure in rats. Scientific Reports In Press
Bushana, P., Koberstein, J. N., Nguyen, T., Harvey, D. O., & Davis, C. J. (2020) Performance on the Mouse Vibration Actuating Search Task (VAST) is compromised by Sleep Deprivation. Journal of Neurophysiology 123, 600-608 PMID: 31891527 PMCID: PMC7052632
Davis, C. J., Zielinski, M. R., Dunbrasky, D., Taishi, P., Dinarello, C. A., & Krueger, J. M. (2017) Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection. Neurobiology of Sleep and Circadian Rhythms 3, 1-9 PMID: 28070566 PMCID: PMC5218600

The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA. Vanderheyden WM, Fang B, Flores CC, Jager J, Gerstner JR. Curr Res Neurobiol. 2021;2:100009. doi: 10.1016/j.crneur.2021.100009. Epub 2021 Mar 23. PMID: 34056625
Koritala BSC, Porter KI, Arshad OA, Gajula RP, Mitchell HD, Arman T, Manjanatha MG, Teeguarden J, Van Dongen HPA, McDermott JE, Gaddameedhi S. Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans. Journal of Pineal Research, 2021; 70: e12726.
Kurinec CA, Whitney P, Hinson JM, Hansen DA, Van Dongen HPA. Sleep deprivation impairs binding of information with its context. Sleep, 2021; 44: zsab113.
Skeiky L, Brager AJ, Satterfield BC, Petrovick M, Balkin TJ, Capaldi VF, Ratcliffe RH, Van Dongen HPA, Hansen DA. TNF? G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study. Chronobiology International, 2020; 37: 1461-1464.
Satterfield BC, Savenkova MI, Karatsoreos IN, Melinda L, Belenky G, Dongen HPA Van, Satterfield BC, Savenkova MI, Karatsoreos IN, Melinda L, Jackson ML, Belenky G. Interleukin-6 (IL-6) response to a simulated night- shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype. Chronobiology International, 2020; 37:1452–1456. doi:10.1080/07420528.2020.1803901.