Muscle, Movement, and Biophysics

Muscle, Movement, and Biophysics

The study of fundamental muscle cell physiology, and how muscles function together to allow action, from contraction of the heart to movement of limbs. Particular research strengths are on understanding the fundamental biophysics of molecular, cellular, and whole-muscle interactions, using quantitative methods to describe the behavior of single molecules as well as movement and posture of humans.

Recent research in this area

  • King-Lun Li, Mei Methawasin, Bertrand C.W. Tanner, Henk L. Granzier, R. John Solaro, and Wen-Ji Dong (2019) Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin Journal of General Physiology 151(1):30-41 PMID: 30523116 PMCID: PMC6314383
  • Lin, D.C., McGowan, C.P., Blum, K.P. and Ting, L.H. (2019) Yank: The time derivative of force is an important biomechanical variable in sensorimotor systems Journal of Experimental Biology doi:10.1242/jeb.180414
  • Javidi, M., McGowan, C.P., Schiele, N.R. and Lin, D.C. (2019) Tendons from kangaroo rats are exceptionally strong and tough Scientific Reports 9(1):8196
  • Javidi, M., McGowan, C.P., and Lin, D.C. (2019) The contributions of individual muscle-tendon units to the plantarflexor group force-length properties Annals of Biomedical Engineering
  • Reda SM, Gollapudi SK, Chandra M (2019) Developmental increase in β-MHC enhances sarcomere length-dependent activation in the myocardium J Gen Physiol 151(5):635-644 PMID: 30602626 PMCID: PMC6504293
  • Reda SM, Chandra M. (2019) Dilated cardiomyopathy mutation (R174W) in troponin T attenuates the length-mediated increase in crossbridge recruitment and myofilament Ca2+ sensitivity Am J Physiol Heart Circ Physiol PMID: 31373515
  • Fenwick AJ, Awinda PO, Yarbrough-Jones JA, Eldridge JA, Rodgers BD, Tanner BCW. (2019) Demembranated skeletal and cardiac fibers produce less force with altered cross-bridge kinetics in a mouse model for limb-girdle muscular dystrophy 2i. Am J Physiol Cell Physiol. 317(2):C226-C234 PMID: 31091146
  • Kieu TT, Awinda PO, Tanner BCW. (2019) Omecamtiv Mecarbil Slows Myosin Kinetics in Skinned Rat Myocardium at Physiological Temperature. Biophys J. 116(11):2149-2160. PMID: 31103235 PMCID: PMC6554472
  • Breithaupt JJ, Pulcastro HC, Awinda PO, DeWitt DC, Tanner BCW. (2019) Regulatory light chain phosphorylation augments length-dependent contraction in PTU-treated rats. J Gen Physiol. 151(1):66-76. PMID: 30523115 PMCID: PMC6314387
  • Schwaner M.J., Lin D.C., and McGowan C.P. (2018) Jumping mechanics of desert kangaroo rats Journal of Experimental Biology 12:221 (Pt 22)
  • Reda SM, Chandra M. (2018) Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca2+ sensitivity J Gen Physiol 150(6):809-819 PMID: 29776992 PMCID: PMC5987878
  • Gollapudi SK, Reda SM, Chandra M. (2017) Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity Biophys J 113(4):880-888 PMID: 28834724 PMCID: PMC5567428
  • Michael JJ, Chandra M. (2016) Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α- and β-Myosin Heavy Chain Isoforms J Am Heart Assoc 5(3):e002777 PMID: 27001966 PMCID: PMC4943253

Faculty working in this area

Robert Catena

Robert Catena

robert.catena@wsu.edu

Assistant Professor

Wen-Ji Dong

Wen-Ji Dong

dongwenji@wsu.edu

Associate Professor

David C. Lin

David C. Lin

davidlin@wsu.edu

Associate Professor

Bert Tanner

Bert Tanner

bertrand.tanner@wsu.edu

Associate Professor

Accepting Graduate Students

Anita Vasavada

Anita Vasavada

vasavada@wsu.edu

Associate Professor