Muscle, Movement, and Biophysics

Muscle, Movement, and Biophysics

The study of fundamental muscle cell physiology, and how muscles function together to allow action, from contraction of the heart to movement of limbs. Particular research strengths are on understanding the fundamental biophysics of molecular, cellular, and whole-muscle interactions, using quantitative methods to describe the behavior of single molecules as well as movement and posture of humans.

Recent research in this area

  • Javidi, M., McGowan, C.P., and Lin, D.C. (2020) Estimation of the force-velocity properties of individual muscles from measurement of the combined plantarflexor properties. Journal of Experimental Biology 223: PMID: 32680898
  • King-Lun Li, Mei Methawasin, Bertrand C.W. Tanner, Henk L. Granzier, R. John Solaro, and Wen-Ji Dong (2019) Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin Journal of General Physiology 151(1):30-41 PMID: 30523116 PMCID: PMC6314383
  • Lin, D.C., McGowan, C.P., Blum, K.P. and Ting, L.H. (2019) Yank: The time derivative of force is an important biomechanical variable in sensorimotor systems Journal of Experimental Biology doi:10.1242/jeb.180414
  • Javidi, M., McGowan, C.P., Schiele, N.R. and Lin, D.C. (2019) Tendons from kangaroo rats are exceptionally strong and tough Scientific Reports 9(1):8196 doi: 10.1038/s41598-019-44671-9 PMID: 31160640 PMCID: PMC6546749
  • Javidi, M., McGowan, C.P., and Lin, D.C. (2019) The contributions of individual muscle-tendon units to the plantarflexor group force-length properties Annals of Biomedical Engineering ;47(11):2168-2177. doi: 10.1007/s10439-019-02288-z. Epub 2019 May 20. PMID: 31111328
  • Reda SM, Gollapudi SK, Chandra M (2019) Developmental increase in β-MHC enhances sarcomere length-dependent activation in the myocardium J Gen Physiol 151(5):635-644 doi: 10.1085/jgp.201812183 PMID: 30602626 PMCID: PMC6504293
  • Reda SM, Chandra M. (2019) Dilated cardiomyopathy mutation (R174W) in troponin T attenuates the length-mediated increase in crossbridge recruitment and myofilament Ca2+ sensitivity Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00171.2019 PMID: 31373515
  • Fenwick AJ, Awinda PO, Yarbrough-Jones JA, Eldridge JA, Rodgers BD, Tanner BCW. (2019) Demembranated skeletal and cardiac fibers produce less force with altered cross-bridge kinetics in a mouse model for limb-girdle muscular dystrophy 2i. Am J Physiol Cell Physiol. 317(2):C226-C234 PMID: 31091146

Faculty working in this area

Robert Catena

Robert Catena

robert.catena@wsu.edu

Assistant Professor

Wen-Ji Dong

Wen-Ji Dong

dongwenji@wsu.edu

Associate Professor

David C. Lin

David C. Lin

davidlin@wsu.edu

Associate Professor

Bert Tanner

Bert Tanner

bertrand.tanner@wsu.edu

Associate Professor

Accepting Graduate Students

Anita Vasavada

Anita Vasavada

vasavada@wsu.edu

Associate Professor