faculty

Murali Chandra

Murali Chandra

Professor

murali@wsu.edu
Office
Room: VBR 251
Phone: (509)-335-7561

 

Current Position

2014-Present Professor, IPN, Washington State University, Pullman, WA
2007-2014 Associate Professor, IPN, Washington State University, Pullman, WA

Research

Dr. Chandra's research focuses on understanding the molecular mechanisms responsible for regulation of the contractile machinery of heart muscle cells, and how myofilament remodeling is linked to pathogenesis of heart diseases. 

Education

1981B.Sc.Chemistry, Karnataka University - Dharwad, India
1983M.Sc.Biochemistry, Karnataka University - Dharwad, India
1989Ph.D.Biochemistry, Australian National Uniersity - Canberra, Australia

Current Funding

NSF Mechanisms of Heat Shock Protein Regulation and Function in Muscles of a Model Teleost (Co-PI)
AHA Targeted in situ/in vivo Reconstitution of Myosin Binding Protein C (MyBPC) in the C-Zone of Cardiac Sarcomeres (Co-I)
CVM Intramural Research Project Targeted In Situ/In Vivo Reconstitution of Myosin Binding Protein C in the C-Zone of Cardiac Sarcomeres (PI)
Select Publications
  • Reda SM, Gollapudi SK, Chandra M (2019) Developmental increase in β-MHC enhances sarcomere length-dependent activation in the myocardium J Gen Physiol 151(5):635-644 doi: 10.1085/jgp.201812183 PMID: 30602626 PMCID: PMC6504293
  • Michael JJ, Chandra M. (2016) Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α- and β-Myosin Heavy Chain Isoforms J Am Heart Assoc 5(3):e002777 doi: 10.1161/JAHA.115.002777 PMID: 27001966 PMCID: PMC4943253
  • Reda SM, Chandra M. (2018) Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca2+ sensitivity J Gen Physiol 150(6):809-819 doi: 10.1085/jgp.201711974 PMID: 29776992 PMCID: PMC5987878
  • Gollapudi SK, Reda SM, Chandra M. (2017) Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity Biophys J 113(4):880-888 doi: 10.1016/j.bpj.2017.07.002 PMID: 28834724 PMCID: PMC5567428
  • Reda SM, Chandra M. (2019) Dilated cardiomyopathy mutation (R174W) in troponin T attenuates the length-mediated increase in crossbridge recruitment and myofilament Ca2+ sensitivity Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00171.2019 PMID: 31373515 PMCID:

List of Publications