faculty
faculty
Murali Chandra
Professor
murali@wsu.edu
Office
Room: VBR 251
Phone: (509)-335-7561
Current Position
2014-Present Professor, IPN, Washington State University, Pullman, WA
2007-2014 Associate Professor, IPN, Washington State University, Pullman, WA
Research
Dr. Chandra's research focuses on understanding the molecular mechanisms responsible for regulation of the contractile machinery of heart muscle cells, and how myofilament remodeling is linked to pathogenesis of heart diseases.Education
| 1981 | B.Sc. | Chemistry, Karnataka University - Dharwad, India |
| 1983 | M.Sc. | Biochemistry, Karnataka University - Dharwad, India |
| 1989 | Ph.D. | Biochemistry, Australian National Uniersity - Canberra, Australia |
Current Funding
NIH Mechanistic Understanding of Troponin T Role in Cardiac Thin Filament Activation, PI
NIH Kinetics of Cardiac Myofilament Activation, Co-PI
Select Publications
- Reda SM, Gollapudi SK, Chandra M (2019) Developmental increase in β-MHC enhances sarcomere length-dependent activation in the myocardium J Gen Physiol 151(5):635-644 PMID: 30602626 PMCID: PMC6504293 doi: 10.1085/jgp.201812183
- Michael JJ, Chandra M. (2016) Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α- and β-Myosin Heavy Chain Isoforms J Am Heart Assoc 5(3):e002777 PMID: 27001966 PMCID: PMC4943253 doi: 10.1161/JAHA.115.002777
- Reda SM, Chandra M. (2018) Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca2+ sensitivity J Gen Physiol 150(6):809-819 PMID: 29776992 PMCID: PMC5987878 doi: 10.1085/jgp.201711974
- Gollapudi SK, Reda SM, Chandra M. (2017) Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity Biophys J 113(4):880-888 PMID: 28834724 PMCID: PMC5567428 doi: 10.1016/j.bpj.2017.07.002
- Reda SM, Chandra M. (2019) Dilated cardiomyopathy mutation (R174W) in troponin T attenuates the length-mediated increase in crossbridge recruitment and myofilament Ca2+ sensitivity Am J Physiol Heart Circ Physiol PMID: 31373515 PMCID: doi: 10.1152/ajpheart.00171.2019