Steve M. Simasko
Room: VBR 205F
Current Positions2003-Present Professor, IPN, Washington State University, Pullman, WA
2008-Present Director, Neuroscience, Washington State University, Pullman, WA
2008-Present Chair, IPN, Washington State University, Pullman, WA
One area of my research is the molecular mechanisms by which nutrient relevant signals activate vagal afferent nerves that innervate the gastrointestinal track. This signaling is an important component in the control of food intake, which if dysregulated, can lead to obesity. The overarching goal of this research is to develop insights that can inform therapeutic interventions that improve body weight regulation and general health.
A second focus is investigating the neuronal basis by which chronic alcohol exposure leads to disruptions of circadian rhythms and sleep quality in a rodent model. Poor sleep in recovering alcoholics has been shown to be increase the likelihood of relapse to drinking. If we can determine the basis for this dysregulation, interventions can be designed that would help recovered alcoholics remain sober for greater periods of time.
Steven M. Simasko, Professor, earned a B.A. degree in chemistry from the Colorado College in 1977, and a Ph.D. degree in pharmacology at the University of Washington in 1983. He was a postdoctoral fellow in the Department of Pharmacology at the College of Veterinary Medicine at Cornell University in Ithaca, NY prior to taking a faculty position in the Department of Physiology in the School of Medicine and Biomedical Sciences at the State University of New York in Buffalo, NY. In 1994 he returned to the west to take a faculty position in the College of Veterinary Medicine at Washington State University.
HHS-NIH Mechanisms of Fatty Acid Control of Feeding, Co-PI
HHS-NIH Asynchronous Glutamate Release in Vagal Afferent, Collaborator
- Mukherjee S, Simasko SM (2009) Chronic alcohol treatment in rats alters sleep by fragmenting periods of vigilance cycling in the light period with extended wakenings Behav Brain Res 198(1), 113-24 PMID: 19014977 PMCID: PMC2661625
- (2010) Role of transient receptor potential channels in cholecystokinin-induced activation of cultured vagal afferent neurons Endocrinology 151(11), 5237-46 PMID: 20881249 PMCID: PMC2954709
- Wiater MF, Mukherjee S, Li AJ, Dinh TT, Rooney EM, Simasko SM, Ritter S (2011) Circadian integration of sleep/wake and feeding requires NPY-receptor expressing neurons in the mediobasal hypothalamus Am J Physiol Regul Integr Comp Physiol 301(5), R1569-83 PMID: 21880863 PMCID: PMC3213939
- Riley TP, Neal-McKenney JM, Buelow DR, Konkel ME, Simasko SM (2013) Capsaicin-sensitive vagal afferent neurons contribute to the detection of pathogenic bacterial colonization in the gut J. Neuroimmunol PMID: 23481698 PMCID: PMC4188534
- Darling RA, Zhao H, Kinch D, Li AJ, Simasko SM, Ritte S (2014) Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors Am J Physiol 307, R35-R43 PMID: 24760994 PMCID: PMC4152161