Suzanne M. Appleyard, Ph.D.

Suzanne M. Appleyard, Ph.D.


Associate Professor
Office: Veterinary and Biomedical Research Building (VBR) room 351
E-Mail: appleyas@vetmed.wsu.edu
Phone: (509) 335-7784
Lab: (509) 335-0905


Current Positions

2013-Present Associate Professor IPN, College of Veterinary Medicine, WSU, Pullman, WA


Research

Dr. Appleyard has been working in the field of energy homeostasis for over 12 years, using both mouse
genetic and electrophysiological approaches. She has extensive experience using transgenic mouse models and in particular mouse models where EGFP (enhanced green florescent protein) is driven by promoters to identify specific neuronal populations, namely both the TH-EGFP (tyrosine hydroxylase) and POMC-EGFP (proopiomelanocortin) mouse models. She has over ten years’ experience investigating NTS function and circuitry using both electrophysiological and immunocytochemical techniques. Dr. Appleyard has over 20 years’ experience investigating signal transduction mechanisms, most recently the molecular mechanisms underlying leptin’s actions, including investigating leptin-induced dendritic spine and synapse formation. Dr. Appleyard also has experience using behavioral techniques to investigate food intake and related behaviors.

Biographical Information

Dr. Suzanne Appleyard completed a B.Sc. in Pharmacology in 1991 at the University College London in the UK. She then went on to complete a Ph.D in Pharmacology and Neurobiology in 1998 from the University of Washington in Seattle. She was a postdoctoral fellow at the Oregon Health and Science University in Portland, Oregon, which led to her appointment as a research assistant professor in the same location. She has been at Washington State University since 2007.


Current Funding

NIH Integration Central Appetite Signals
ADARP Effect of chronic nicotine exposure
CVM Intramural Project

Publications
Click here for a link to Dr. Appleyard's publications

  1. Zhao, H., Peters, J.H., Zhu, M., Ritter, R.C. and Appleyard S.M. (2015) Frequency-dependent facilitation of synaptic throughput via postsynaptic NMDA receptors in the nucleus of the solitary tract. In Press in J. Physiol.  593(1):111-25
  2. Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard S.M., Wright JW, Wayman GA, Harding JW. (2014)  The pro-cognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system.  J Pharmacol Exp Ther. 114.218735. PMID: 25187433
  3. Guimond, D., Diabira, D., Porcher, C., Bader, F., Ferrand, N., Zhu, M., Appleyard, S.M., Wayman, G.A., Gaiarsa, J.L. (2014) Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus.  Front Cell Neurosci. 8:235. PMID: 25187433.
  4. Dhar, M., Wayman, G.A., Zhu, M., Lambert, T.J., Davare, M.A. and Appleyard, S.M. (2014) Leptin-induced spine formation requires TrpC channels and the CaM Kinase cascade in the hippocampus. J. Neuroscience. 34(30):10022-33. PMID: 25057204.
  5. Ho, J.M., Anekonda,V.T. Thompson, B.W., Zhu, M., Curry, R.W., Hwang, B.H., Morton, G.J., Schwartz. M.W., Baskin, D.G., Appleyard, S.M., Blevins, J.E. (2014) Hindbrain oxytocin receptors mediate the effects of circulating oxytocin on food intake in male rats.  Endocrinology. 155(8): 2845-57. PMID: 24877632.
  6. Dhar, M., Zhu, M., Lambert, T.J., Davare, M., Appleyard, S.M., and Wayman, G.A. (2014) Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132. Molecular Endocrinology (7):1073-87. PMID: 24877561
  7. Lesiak, A., Zhu, M., Chen, H., Appleyard, S.M., Impey, S., Lein, P.J. and Wayman, G.A. (2014) The environmental Neurotoxicant, PCB95, Promotes Synaptogenesis Via Ryanodine Receptor-Mediated Activation of CREB-Dependent miR132 Upregulation. J. Neuroscience 34(3):717-25.
  8. Lesiak, A., Pelz, C., Ando, H., Zhu, M., Davare, M., Lambert, L. Dwyer, J., Obrietan, K., Appleyard, S.M., Impey, S. and Wayman, G.A.  (2013) A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Pard6A and Rnd3 as novel regulators of BDNF-induced synaptogenesis. PLoS One 8(6):e64658.
  9. McCoy, A.T., Benoist, C.C., Wright, J.W., Kawas, L.H., Bule-Ghogare JM, Zhu M, Appleyard S.M., Wayman, G.A., Harding, J.W.  (2013) Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharm. Exp Ther. 344(1):141-54.
  10. Cui, R.J., Roberts, B.L., Zhao, H., Zhu, M., and Appleyard, S.M. (2012) Serotonin activates catecholamine neurons in the Solitary Tract Nucleus by increasing spontaneous glutamate inputs.  J. Neuroscience 32(46):16530-8